Nephrotic Syndrome in Children

Nephrotic syndrome is a triad of:

  1. Massive Proteinuria ( >1g/m2 per 24ours )
  2. Hypoalbuminaemia ( <25g/l )
  3. Oedema

Other Features:

  1. Hyperlipidaema,
  2. hypercoagulability (due to loss of antithrombin III),
  3. predisposition to infection.

Peak incidence: 2-5years of age

Around 80% are due to minimal change glomerulonephritis

90% respond to high dose oral steroids and have good prognosis