What is the most common malignancy in childhood?
Acute Lymphoblastic Leukaemia
2. Of the childhood leukaemias, what proportion is ALL?
2A: ALL accounts for 80 of childhood leukaemias
3: What is the peak age group for ALL?
3A: peak age is between 2 and 5 years
4. Is ALL seen equally in boys and girls?
4A: ALL is slightly more common in boys
5: What are the clinical features of ALL divided into?
5A: ALL’s clinical features can be divided into those resulting from bone marrow failure and Other features.
6: what are the clinical features resulting from bone marrow failure?
6A: The clinical features of ALL related to failure of the bone marrow are: Anaemia – lethargic/pallor, Neutropenia – Frequent/severe infections and thrombocytopenia – easy bruising/petechiae
7: what are the other features of ALL?
7A: Bone pain, Hepatomegaly, Splenomegaly, Testicular swelling
8; What are the types of all? (quick)
8A: 1. Common ALL, 2 T-cell ALL, 3. B-cell ALL
9: What are the relative percentages of the different types of ALL?
9A: Common is 75%, T-cell ALL is 20% (T for T-cell ad T for Twenty percent), B-cell 5%.
10: What are the poor prognostic factors for a kid presenting with Acute Lymphoblastic Leukaemia?
10A: Age less than 2 or more than 10, B or T cell surface antigen positive, Male, Non -caucasian