Kleinfelter’s Syndrome

Kleinfelter’s Syndrome

  • Usually 47XXY (sometimes others)
  • Most common cause of hypogonadism in males
  • Often undiagnosed as subtle symptoms (diagnosis made post-mortem)
  • Normal life expectancy

Lack of testosterone leads to osteoporotic fractures

Also increased risk of:

  • testicular cancer
  • Autoimmune disorders like SLE / diabetes
  • Male breast cancer

Kleinfelter’s patients may still be able to father children using modern sperm extraction techniques.

Androgen replacement therapy is the mainstay of treatment.