Kawasaki Disease

Kawasaki Disease

Rare vasculitic syndrome of childhood causing prolonged fever which can lead to death from coronary artery aneurysm.


  • Irritability (this is the one thing that will be almost diagnostic – between febrile episodes, the Kawasaki patient will remain irritable; where as normally they will settle a bit when afebrile).
  • High grade fever lasting for >5days – characteristically resistant to antipyretics
  • conjuctival injection
  • bright red, cracked lips
  • strawberry tongue
  • cervical lymphadenopathy
  • red palms of the hands and the soles of the feet which later peel

Diagnosis is clinical – no specific test to confirm

Management of Kawasaki disease

One of the rare indications for use of aspirin in children

(due to the risk of Reye’s syndrome, aspiring is usually contraindicated in children)

  • high-dose aspirin
  • intravenous immunoglobulin
  • echocardiogram (rather than angiography) is used as the initial screening test for conronary artery aneurysms


  • coronary artery aneurysm


All red + cervical lymphadenopathy (red eyes, red mouth, red hands, red rash and cervical lymphadenopathy)